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ADVANTIX® both repels and kills ticks; DIRECTIONS FOR USE For very large dogs over 50 kg, apply 2 tubes of ADVANTIX® for Dogs Over 25 kg. While the dog is standing, separate a patch of hair on the back of the dog's neck between his or her shoulder blades. Once a patch of healthy skin is visible, How to apply · a) For dogs less than 25 kg (under 55 pounds): with your dog standing, apply the entire tube to one spot on your dog's back between the shoulderCall a poison control center or doctor for treatment advice. To Physician: Treat the patient symptomatically. DIRECTIONS FOR USE. It is a violation of Federal Evenly apply the entire contents of the tube along the top of the dog's back, from the shoulder down to the base of the tail. The number of spots depends on the Advantix is a spot-on treatment that is applied to your dog's skin and kills fleas and ticks on contact. Advantix also repels ticks, including the deadly Topical prevention and treatment of ticks, fleas, mosquitoes, biting flies and lice for monthly use only dogs and puppies 7 weeks of age and older.