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IA64 = the Intel/HP Itanium VLIW architecture. AMD64 is the AMD developed extention of the standard x86 instruction set. – talonmies. Jan 29 '12 at 17:33. ARM is the top CPU designer for smartphones, Intel is the big name in PCs. What's the difference? Find out in this Arm vs x86 comparison! For the most part, compatibility is good between Intel and AMD processors. There are some key differences between processors from the two vendors,The x86-64 architecture is distinct from the Intel Itanium architecture (formerly IA-64). The architectures are not compatible on the native instruction set We put AMD vs Intel in a battle of processor prowess. completely redefining x86 desktop PC chips with a new hybrid architecture.