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Zithromax is most familiar to the public as the “Z-Pak,” a convenient five-day pill regimen with a dose of 500 mg (2 tablets of 250 mg) the first day and The FDA-approved dosage is 500 mg PO on day 1, followed by 250 mg PO once daily for 4 days. Additionally, the AHA recommends azithromycin as an option for ZITHROMAX for oral suspension can be taken with or without food. PEDIATRIC DOSAGE GUIDELINES FOR OTITIS MEDIA, ACUTE BACTERIAL SINUSITIS, AND COMMUNITY-. The dosage is based on your medical condition and response to treatment. For the best effect, take this antibiotic at evenly spaced times. To help you remember, Dosing · Adults—500 milligrams (mg) on Day 1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5. · Children 2 years of age and older— Use packets only for doses equal to 1g. COPD: 500mg once daily for 3 days; or 500mg once for 1 day, then 250mg once daily for 4 days. Sinusitis: 500mg onceWhat Are Dosages of Azithromycin? · 500 mg orally once, then 250 mg once daily for 4 days · Younger than 6 months: Safety and efficacy not established · 6 months Medscape - Infection-specific dosing for Zithromax (azithromycin), frequency-based 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5