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The WHOQOL-BREF is a self-administered questionnaire comprising 26 questions on the individual's perceptions of their health and well-being over the previousThe measure is calculated by summing the point values for the questions corresponding to each domain and then transforming the scores to a 0-100 point interval, This manual was drafted by Alison Harper on behalf of the WHOQOL group. The version of the WHOQOL-BREF, instructions for administering and scoring, and. Instructions. This questionnaire asks how you feel about your quality of life, health, or other areas of your life. Please answer all the questions. As you know there are 26 questions on the WHOQOL-BREF, each scored from 1-5, comprising 4 domains. The domain scores are not averages, they are the sum total