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In 1943, Lofgren introduces lidocaine, the prototypical amide local anesthetic. Development of local anesthetics, since the 1950?s, has focused on amide local. PDF | The development of safe and effective local anesthetic agents has possibly been the most important advancement in dental science to occur in the. This led to the development of levobupivacaine and ropivacaine. Today many local anesthetic agents, including both ester and amide types, are available.