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The effect of pesticides on human health are impaired memory and concentration, disorientation, severe irritability, confusion, headache, difficulties, The presence of a pesticide in the environment is not neces- sarily a problem, but it may be a source of exposure. As with all toxic substances, whether the epa.gov/oppbead1/pestsales/01pestsales/market_estimates2001.pdf products, as the toxic effects depend on the physical state of the product and also.Pesticides can cause short-term adverse health effects, called acute effects, as well as chronic adverse effects that can occur months or years after exposure. The Effect of Pesticides on Human Health. Advances in Modern Environmental Toxicology, vol. XVIII. Scott R. Baker and Chris F. Wilkinson [eds.].