[Kindle] Drug-Like Properties: Concepts,
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Li Di, Edward H Kerns
Drug-Like-Properties.pdf
ISBN: 9780128010761 | 580 pages | 15 Mb
- Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
- Li Di, Edward H Kerns
- Page: 580
- Format: pdf, ePub, fb2, mobi
- ISBN: 9780128010761
- Publisher: Elsevier Science
Epub books free download for android Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods
Real World Drug Discovery: A Chemist's Guide to Biotech and
Drug discovery increasingly requires a common understanding by Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Structure Design and Methods: from ADME to Toxicity Optimization by Li Di
Drug-like Properties: Concepts, Structure Design and Methods
Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization, 作者: Edward Kerns,Li Di, 版本: 1, Academic Press, Of the
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Drug-like properties: concepts, structure design & methods - Lavoisier
Livre : Drug-like properties: concepts, structure design & methods: From ADME to toxicity optimization KERNS Edward, DI Li.
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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization. By: Edward Kerns & Li Di. Price. $180.90. Binding. Ebook.
Drug-like properties : concepts, structure design and methods
Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization. フォーマット: 図書; 責任表示: Edward H. Kerns
Drug-like Properties: Concepts, Structure Design and Methods
The online version of Drug-like Properties: Concepts, Structure Design and Methods by Edward H. Kerns and Li Di on from ADME to Toxicity Optimization.
Drug-Like Properties Concepts, Structure Design and Methods
Drug-Like Properties Concepts, Structure Design and Methods - From ADME to Toxicity Optimization. Book in english language. Di, Li.
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Drug-like properties : concepts, structure design and methods
Drug-like properties : concepts, structure design and methods : from ADME to toxicity optimization. By Edward Harvel Kerns; Li Di. Print book. 영어. 2008.
Drug-like Properties Concepts, Structure Design and Methods from
Kerns, Edward. Drug-like properties: concepts, structure design, and methods: from ADME to toxicity optimization/Edward Kerns and Li Di.—1st ed. p. ; cm.
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