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Easy and comprehensive hard disk partition manager to partition hard drive safely and migrate OS to SSD without losing data. RSC Advances. Particle size characterization of nanoparticles- a practicalapproach. Iranian Journal of Materials Science and Engineering.

Alfauziah, T. Majalah Farmasetika, 3 5 , Anugraheni, I. E-Jurnal Pustaka Kesehatan, 5 1 , — Azarmi, R. Type and application of some common surfactants. Journal of Chemical and Pharmaceutical Research. Chen, H. Nanonization strategies for poorly water-soluble drugs. In Drug Discovery Today. Institut Teknologi Sepuluh Nopember Surabaya. Cremophor RH Indonesian Journal of Chemical Science. Date, A. Self- nanoemulsifying drug delivery systems: Formulation insights, applications and advances.

Nanomedicine, 5 10 , — Nutraceutical delivery systems: Resveratrol encapsulation in grape seed oil nanoemulsions formed by spontaneous emulsification. Food Chemistry. Depkes RI. Farmakope Indonesia Edisi V. In Farmakope Indonesia Edisi V. Nanoemulsions: as modified drug delivery tool. Pharmacie Globale. Devi, I. Eid, A. Preparation and evaluation of olive oil nanoemulsion using sucrose monoester.

International Journal of Pharmacy and Pharmaceutical Sciences, 5, — Inovasi Teknik Kimia, 2 1 , 9— Flora, G. Grumezescu, A. Nano- and microscale drug delivery systems: Design and fabrication.

Self-nanoemulsifying drug delivery system for adefovir dipivoxil: Design, characterization, in vitro and ex vivo evaluation. Journal of Pharmacopolium. Periodica Polytechnica Chemical Engineering. Karakterisasi Nanoemulsi Ekstrak Daun Kelor.

Emulsion micro emulsion and nano emulsion: A review. In Systematic Reviews in Pharmacy. Universitas Sanata Dharma Yogyakarta. Kesumawardhany, B. Kumar, A. Curcumin loaded nano globules for solubility enhancement: Preparation, characterization and Ex vivo release study.

Journal of Nanoscience and Nanotechnology. Jurnal Kimia, 12 1 , 8— Majalah Farmasetika. Nurfauziah, R. Farmaka Suplemen, 16, — Patel, J. Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan.

Journal of Advanced Pharmaceutical Technology and Research. Microemulsion: as excellent drug delivery system. International Journal for Pharmaceutical Research Scholars. Perdana, Y. Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase. Formulasi dan uji penetrasi natrium diklofenak dalam emulsi dan mikroemulsi.

In Universitas Indonesia Skripsi. Rachim, P. Pembuatan surfaktan natrium lignosulfonat dari tandan kosong kelapa sawit dengan sulfonasi langsung. In Jurnal Teknik Kimia. Rachmawati, H. Curcumin nanoemulsion for transdermal application: Formulation and evaluation. Drug Development and Industrial Pharmacy.

Valorisation of wheat bran into surfactant molecules. Reningtyas, R. Eksergi, XII 2 , 12— Rowe, R. Handbook of Pharmaceutical Excipients 6th Ed. In Handbook of Pharmaceutical Excipients. Handbook Of Pharmaceutical Exipients. Sahumena, M. Journal Syifa Sciences and Clinical Research, 1 2 , 37— Savardekar, P. Nanoemulsions-a Review. International Journal of Research in Pharmacy and Chemistry.

Sekhon, B. Surfactants: Pharmaceutical and Medicinal Aspects. Journal of Pharmaceutical Technology, Research and Management. Mixed surfactant based SNEDDS self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability.

Biomedicine and Pharmacotherapy. Colloids and Surfaces B: Biointerfaces. Nanoemulsion: A pharmaceutical review. Sinala, S. Singh, Y. Journal of Controlled Release, , 28— Nanoemulsion formation by low-energy methods: a review. Basmi Kanker dengan Herbal. Suzetti, E. Swardini, Z. Universitas Jember. Swasono, A. Formulation and characterization of lipid-based drug delivery system of raloxifene- microemulsion and self-microemulsifying drug delivery system.

Journal of Pharmacy and Bioallied Sciences. International Journal of Research in Pharmacy and Science. Pengujian Organoleptik. In Universitas Muhammadiyah Semarang. In Universitas Ngudi Waluyo. Development and evaluation of nanoemulsifying preconcentrate of curcumin for colon delivery. Scientific World Journal. Analytical Chemistry. Uji aktivitas antioksidan senyawa campuran derivat kurkumin dan katekin hasil isolasi dari daun teh Camellia sinensis.

In Universitas Indonesia. Wulansari, S. Kimia Riset, 4 2 , — Yuliani, S. Traditional Medicine Journal. Jurnal Penelitian Tanaman Industri, 20 3 , — Media Farmasi Indonesia, 14 1 , — Published on 28 June Clove oil oil , Tween surfactant , and PEG co-surfactant were selected on the basis of their solubility and maximum nanoemulsion region.

An aqueous micro-titration method with high-energy ultrasonication was used for the preparation of Cur-NE. The optimized NE had parameters of 5. On the basis of experimental data of the dependent variables, we calculated a hydrodynamic diameter of In conclusion, Cur- DOI: The breakdown of this complicated pathway diseases and diabetes mellitus.

In general, older people can might be responsible for the failure of wound healing, be successfully treated with surgery when they have non- leading to non-healing wounds. Wound repair involves healing chronic wounds. Faisal University, P. Box , Dammam, Kingdom of Saudi Arabia E-mail: nanhussain iau. It was reported that NE is only stable kinetically. Now, new vascularization and also increases the process of re- most researchers report the need for external energy during epithelialization of wounds.

Therefore, a formulation employment of a central composite design. A few drops of potent essential oil, penetrate into the skin via the subcutaneous barrier. Aromatherapy is the best encapsulation of active constituents are a novel drug example of an alternative treatment system to improve the delivery approach.

Moreover, the optimized Cur-NE was used to further conventional topical preparations e. The solubility of poorly water-soluble system with an ex vivo skin permeation study.

Cur-NE was drugs can be increased by NEs, in which drugs are developed and optimized with the use of safe and nontoxic dispersed in an oil droplet phase. Milli-Q water during wound healing. PEG, Tween, and other surfactants Microemulsion and nanoemulsion were previously were purchased from Sigma Life Science, Sigma Aldrich considered to be two interchangeable terminologies; now, Belgium.

Oleic acid, olive oil, almond oil, castor oil, clove used for a coarse Cur-emulsion. Concisely, to 1. Therefore, Cur-NE is kinetically stable, which is microcentrifuge tube was added a maximum amount of Cur.

Centrifuge of the mixtures for We used to optimize the parameters of nanoformulations in prepared a correct dilution for the UV-absorbance at nm pharmaceutical research.

In brief, into a screw capped glass vial and polydispersity index PDI as dependent variables, 5. Oil and Smix were correctly mixed. Similarly, the amount of oil and Smix was also as process variables. Composition of oil and surfactant were varied 1 : 9, 1 : 7, 1 : 8, 1 : 6, 1 : 3. Therefore, all the of the microtitration and placebo nanoemulsions were constraints correlate as per requirements for the optimiza- prepared.

Cur was dissolved in oil and S mix in Oil Surfactant Co-surfactant code Zeta potential a glass vial and a mixture was obtained which is micro- titrated with Milli-Q-water to achieve a coarse emulsion. The sample was observed again using TEM.

The sputter unit was pre-maintained with Argon gas for s at 50 mA. In order to get an idea regarding the Open Access Article. The blank used was distilled water and no dilution for any formu- Fig. In vitro release of drug from optimized NE was performed using a pre-treated dialysis membrane pore size: 2. The temperature was maintained at As mentioned by Ahmad et al. An average 0. At every time point, we withdrew test samples 1 Particle surface charge zeta potential measurements. The mL.

Refractive index RI and applied to measure the zeta potential through electrophoretic viscosity test was performed using the method of Ahmad mobility measurements. In brief, the samples were kept in the pan Open Access Article. We were followed the Evaluation of wound healing area. Evaluation of the wound Ahmad et al. Albino rats weight; kg 1 body wt and a marketed preparation of the antibiotic — g were grouped 5 to 10 in each cage and maintained Fusidic Acid Fusidin: 10 mg kg 1 body wt serving as the in a natural light and dark cycle with free access to food and positive control.

Wistar rats female albino; weight: All g were used in this research. Five groups 6 rats in each group; 6 animals were kept under laboratory prescribed conditions. Before making the wounds on the rats, we condition using freely moving animals.

Excision of the wound was Histomorphological evaluation of tissues. We were then stained by HE Hematoxylin Eosin , followed by determined the wound area on every third day by using a butter analysis using a light microscope. The healed area of tissues was Total wound healing area and closing area were determined.

At all times the rats had unlimited access to calculated. Each female rat served as its own control. Paw food and water, while the temperature was maintained at Finally, we maintained these labora- for each female rat to evaluate all sampling time points. All outcomes were evaluated and repre- waking cycle of the freely moving rats. Paw thick- nanoemulsion ness was evaluated every 4 h through Digital Plethysmograph Curcumin solubility was determined in various oils oleic acid, UGO Basile, Italy and the percentage change of edema was also castor oil, olive oil, almond oil, clove oil, coconut oil, isostearyl Table 4 Best optimized and predicted batch of Cur-NE with independent variables, and dependent variables Independent variables Dependent variables Batch X1 X2 X3 X3 X3 Y1 Y2 Y3 Predicted 5.

This combination maximum solubility, followed by PEG Because of its was previously used by other studies32,34 in which a co-surfactant Open Access Article.

These microemulsions exhibited a very small zeta these properties, Tween was selected as the surfactant. Non-ionic surfactants will produce a very small zeta The zeta potential is also an important parameter to deter- potential on the charge of the surface, followed by reducing the mine in order to estimate the total surface charge and stability particle size of NE.

For the optimized Cur-NE formula- tion, the zeta potential values were found to be The optimization of placebo nanoemulsion highest value of the zeta potential was found for the Cur-NE Various ratios of Smix were graphically represented on the basis OlNE3 The negative zeta potential values in of pseudo-ternary phase diagrams, i. Smix ratios of 1 : 2 to 4 : 1 fatty acid esters in clove oil. Expansion of the Additionally, oil and co-surfactant screening was based on nanoemulsion region is due to parallel increment of the HLB the zeta potential to prepare a stable nanoformulation.

The scale value, i. Clove oil was selected ternary phase diagram. The experimentally observed values for globule size Y1: In addition, for the nanoemulsion formula in Fig. A classic dye test was performed using methylene blue dye Likewise, we saw an increase in sonication time with water soluble for optimized Cur-NE characterization.

In addition, spreading of the dye was Fig. This magnitude of droplet charge. On the other side, among dependent Fig. The drug content Cur was Moreover, the 0. Cur showed a sharp endothermic peak at Pure clove oil and pure Cur-S ture of curcumin. DSC was also performed on Tween This means 0. On the other side, the in vitro epithelization period are shown in Fig. Finally, These results suggest that the developed nano- Cur from Cur-NE.

The production of wound contraction using pure delivery. Humans were NOT used in this research study, The fusidic acid treated rats revealed well-formed healed only animals rats were used. Singh, R. Govindarajan, V. Nath, A. Pathan, S. Munde, S. Shelke, W. Ambekar and Open Access Article. Cur-NE exhibited C. Cur-NE evaluation, Int. Gould, P. Abadir, H. Brem, et al. Conclusion 4 J. Boateng and O. Stejskalova and B. Almquist, Using biomaterials to The highest NE region was shown in Smix 4 : 1 ratio from rewire the process of wound repair, Biomater.

Saporito, G. Sandri, M. Bonferoni, S. Rossi, C. Boselli, niques. Icaro Cornaglia, B. Mannucci, P. Grisoli, B. Further F. Fitzmaurice, R. Sivamani and R. Thomas, F. Zakir, M. Mirza, M. Anwer, F. Ahmad control. These Macromol. All the 9 D. Gopinath, M. Ahmed, K. Gomathi, K. Chitra, results are based on the topical delivery of curcumin from P. Sehgal and R. In parallel, optimized Cur-NE exhibited Biomaterials, , 25, — Sidhu, A.

Singh, D. Thaloor, K. Banaudha, edema compared with Cur-S in the carrageenan-induced rat- G. Patnaik, R. Srimal and R. Maheshwari, paw edema model. Enhancement of wound healing by curcumin in animals, Wound Repair Regen. Gong, Q. Wu, Y. Wang, D.