What is rnd disease
Both RSD and CRPS are chronic conditions characterized by severe burning pain, most often affecting one of the extremities arms, legs, hands, or feet. There are often pathological changes in bone and skin, excessive sweating, tissue swelling and extreme sensitivity to touch, known as allodynia. RSD is sometimes called Type I CRPS, which is triggered by tissue injury where there is no underlying nerve injury, while Type II CRPS refers to cases where a high-velocity impact such as a bullet wound occurred at the site and is clearly associated with nerve injury.
Type II used to be called "causalgia" and was first documented over years ago by doctors concerned about the pain that Civil War veterans suffered even after their wounds had healed. RSD is unusual in that it affects the nerves, skin, muscles, blood vessels and bones at the same time.
The key symptom is, chronic, intense pain that is out of proportion to the severity of the injury if an injury occurred and which gets worse over time rather than better. It most often affects the arms, legs, hands or feet and is accompanied by:. The cause of RSD is not known. The condition is thought to be a malfunctioning of the sympathetic nervous system, but some researchers are questioning this. Some of the most common symptoms are burning and sharp pain in the affected area, sensitivity, tenderness, swelling, tight, shiny skin and redness.
As the disorder progresses, the skin may thicken, and, without regular exercise, the affected area will begin to atrophy and become unusable. Over time, there may also be changes in the bones near the painful area. Some children will experience all of these symptoms, while others may only experience intense pain or burning in the part of the body affected with RND. Because the symptoms of RND so closely resemble so many other conditions, or because it can be misdiagnosed as lingering pain from a recent surgery or other injury, it can be very difficult to get an accurate diagnosis.
There are no tests for this condition, and the only diagnostic sign might be the changes to the bones near the affected area, a symptom that not everyone has.
Diagnosis is most often a matter of eliminating other possibilities until all that remains is RND. There is no cure. The kidneys grow larger and gradually lose the ability to function as they should. Kidney disease occurs when a disease or condition impairs kidney function, causing kidney damage to worsen over several months or years. For some people, kidney damage can continue to progress even after the underlying condition is resolved. Certain factors increase the risk that chronic kidney disease will progress more quickly to end-stage renal disease, including:.
Kidney damage, once it occurs, can't be reversed. Potential complications can affect almost any part of your body and can include:. If you have kidney disease, you may be able to slow its progress by making healthy lifestyle choices:. End-stage renal disease care at Mayo Clinic. Mayo Clinic does not endorse companies or products.
Advertising revenue supports our not-for-profit mission. This content does not have an English version. This content does not have an Arabic version. Overview End-stage renal disease, also called end-stage kidney disease or kidney failure, occurs when chronic kidney disease — the gradual loss of kidney function — reaches an advanced state.
Request an Appointment at Mayo Clinic. Healthy kidney vs. Polycystic kidney Open pop-up dialog box Close. Polycystic kidney A healthy kidney left eliminates waste from the blood and maintains the body's chemical balance. Share on: Facebook Twitter. Show references Goldman L, et al. Chronic kidney disease. In: Goldman-Cecil Medicine.