Why does ivf fail with good embryos

There are several factors that can result in a failed embryo implantation. Not just once, some women often experience repeated implantation failure during their IVF treatment, a condition known as Recurrent Implantation Failure. A woman undergoing such fertility treatment needs to undergo three or more failed implantations to consider their body undergoing an Embryo Implantation Failure. There are two primary reasons that can lead to failed implantation - chromosomal defects in the embryo or the endometrium not being receptive.

So, if your body is not accepting the embryo and resulting in recurrent implantation failure, it is important that you consider discussing the same issues with your fertility specialist. This is a condition wherein the ovary has lower reserves of developed follicles during the stimulation phase of the fertility treatment.

This results in cancelled egg retrieval. Any kind of underactive ovarian function plays a pivotal role in a failed IVF treatment. IVF Cycle Cancellation leads to a delayed cycle. Although the cancellation of IVF cycles can be extremely disheartening and discouraging, it is always better to have a healthy fertilization and implantation procedure instead of experiencing another failure.

Now that you know the possible reasons behind IVF failure even with healthy embryos, it is important that you know what to do next. Although listening to your doctor talking about another failed IVF cycle can be extremely tough to hear, it is necessary that you let the specialist tell you about the issues and where you can go from there to ensure a successful conception.

Keep in mind that the next step in your IVF treatment journey after a failure is guided by the cause behind the failure. Give Another Try - If this is your first failure at the IVF treatment, chances are that your infertility specialist will suggest undergoing another cycle of treatment.

As women age the incidence of chromosomal abnormalities in mature eggs increases significantly. Studies have shown that starting in the early 30s, the rate of chromosomal abnormalities in human eggs and therefore in human embryos starts to increase significantly. It is believed that this is mainly due to problems with the spindle apparatus in the egg nucleus. The spindle is involved with properly lining up and segregating the chromosomes as the egg matures at the time of ovulation. This leads to eggs that do not have the proper balance of 23 chromosomes — and will result in a chromosomally abnormal embryo if fertilized.

PGS — preimplantation genetic screening can be done on embryos prior to transfer to evaluate chromosomal competence. Ovarian hyperstimulation syndrome, or OHSS, is a condition with enlarged ovaries and fluid build up. Ovarian hyperstimulation syndrome, OHSS, is a complication that can occur with in vitro fertilization The. Patient Resource Center. Patient Portal. Request a Consult. IVF - Blog. Failed IVF is a frustrating situation for couples and their fertility doctors.

Prev Previous. I have had an ectopic pregnancy with loss of left tube, follower by a partial molar miscarriage and then a year later a triploidy miscarriage. I was diagnosed with ashermans after second D and C and had minor scar tissue removed. Since then I have had 4 embryo transfers with one resulting in a chemical pregnancy and the rest failing. Embryos were pgta normal and of good quality. My lining gets to around 7. Im at a loss here and so frustrated.

How is it possible that I can get pregnant easily naturally but not with normal embryos? Any advice or next steps I should be taking would be appreciated. The second round of treatment I had 20 eggs, a similar number fertilised, 6 survived to 5 day blastocysts, only 1 tested normal and 2 mosaic with PGS test.

They prepared me for the first transfer, hormone levels good, uterine lining perfect, did make me lay down for 2 and a half hours after and desperately needed the bathroom, but anyway, 1st attempt failed. Just had the 2nd normal embryo transfered last week, everything perfect, HCG test at zero today 8 days post transfer. We used a donor that had allegedly gone through the most stringent sperm tests, who has also reported pregnancies. My wife has also undergone two ICSI procedures, similar numbers to mine, 1st round out of 4 only 1 mosaic, the rest abnormal.

Her second round of treatment, 4 in total, 3 normal with PGS test. She is yet to do the transfer. Perhaps what you mentioned above? Any help would be much appreciated as spent most of the day crying and feeling so lost! Thank you. Immunologic implantation dysfunction IID. Here, activated uterine natural killer cells NKa release excessive TH-1 cytokines that attack the embryo and prevent it from attaching. All Skype consultations are followed by a detailed written report that meticulously describes and explains my recommendations for treatment.

Through SFS I am now able to conveniently provide those who because of geography, convenience and cost, prefer to be treated at home or elsewhere by their chosen Infertility Physician. Anyone wishing to schedule a Skype consultation with me, can do so by: Calling my concierge Patti Converse at in the U. A or Canada or , for an appointment. I have a history of secondary infertility. I also have celiac disease. After 8 months of trying naturally, I conceived and delivered a healthy child in I have been trying for my second child for nearly 2 years.

In the first year, I experienced 2 chemical pregnancies. I then sought out an RE. Given my history of repeated chemical pregnancies and an autoimmune disorder, I suspected immunological issues. I switched REs, to one more open to exploring such issues, and underwent another IVF cycle with 3 embryos that made it to 5-day blast, 2 of which were PGS normal. I just underwent my first failed FET of a single embryo — I did intralipid infusion, dexamethasone, Lovenox, antibiotic as part of the protocol.

We now have one remaining embryo frozen and I am seeking your advice on protocol for my next FET cycle. I feel dismayed that we already threw in what I understand to be the "kitchen sink" to address any underlying immunological problems and it did not work.

I appreciate your advice on what else we should try for our next FET. The most common causes of implantation dysfunction are: a. If you are interested in my advice or medical services, I urge you to contact my patient concierge, ASAP to set up a Skype or an in-person consultation with me.

You can also set this up by emailing concierge sherivf. Dear Dr. Sher, I am 30 years old. Since 4 years, I am trying to get pregnant. I had bad menstrual pains, pains during urination and bowel movement. I took birth control pills for a year and stopped as we want to try for a baby.

It never happened, so I approached fertility clinic where they told my hormones are great but maybe, I have endometriosis. They did laparoscopy last year February and told me I have endo stage 3 with kissing ovaries and fallopian tubes need pressure to pass the dye they used for testing. They suggested me to go for IVF. I also got mild ovarian hyperstimulation due to 15 eggs in which 6 were fertilized. My fresh cycle and cryo cycle showed positive hcg:4 after 14th day of ET failed.

I got pregnant in my 2nd cryo cylcle this year January. I was so happy that it finally worked. I was devastated, depressed. I had extreme pains during all surgeries including egg retrieval. Now after 3 months, trying to cope up with the current situation my Endo pain started.

I am having really bad pain during bowel movement and urination. I visited my fertility specialist, she told my ovaries were a bit bended and were sticking to uterus. She also tested for NK cells and the test came positive. Can I proceed to other IVF cycle with an intralipid treatment or do I have to go for another laparoscopic surgery before it?

Whenever, I have this pain it remembers me that I am unable to become pregnant. I really hate this… Please suggest me what can I do. Do you think it makes sense to go with intralipid treatment for my stage 3 endo? Thank you Sara. When women with infertility due to endometriosis seek treatment, they are all too often advised to first try ovarian stimulation ovulation Induction with intrauterine insemination IUI ………as if to say that this would be just as likely to result in a baby as would in vitro fertilization IVF.

Nothing could be further from reality It is time to set the record straight. And hence this blog!