What does edta chelate

Chelation therapy usually requires intravenous medication several times a week for months at a time. Keep in mind that most insurance plans only cover the use of chelation therapy for FDA-approved conditions, which tend to involve some type of poisoning.

These treatments are given in a medical facility for poisoning. In addition, chelation therapy carries some serious risks. Environmental and industrial factors expose you to high levels of heavy metals every day, including the foods you eat and air you breathe…. Copper is a mineral that your body must have to function properly. Getting copper in trace amounts is essential. Getting too much of it or not enough….

Detoxification detox diets and cleanses are more popular then ever before. They are claimed to improve health by removing toxins from the body. Dementia is a condition that is more common in elderly adults. It involves a decline in your ability to think, or cognition, and your memory. Treat symptoms of bronchitis at home with these 10 remedies, and learn about other treatments. Pulmonary function tests PFTs are a group of tests that measure how well your lungs work.

Learn about the different types. In some cases, chelators are also used during the oxygen delignification stage. It should be born in mind that the Scandinavian pulp and paper industry alone used 23, tons of chelating agents during 3 which is close to the 26, tons of the total consumption of EDTA in Western Europe in 4. There is increasing concern about the direct or indirect potential effects of the presence of EDTA in the environment.

Numerous field studies have shown that complexation with EDTA may mobilize contaminant metal ions. EDTA may avoid the precipitation of heavy metals in solution or, on the contrary, cause a dissolution effect of heavy metals adsorbed in sediments 7,9, Hence, the result is an enhanced mobilization of heavy metals.

Attention has also been paid to the fact that EDTA can solubilize radioactive metals and increase their environmental mobility Another aspect to be considered, is the possible contribution of EDTA in eutrophication water processes. EDTA would also have an indirect effect, when it redissolves the calcic and ferric phosphates, releasing phosphorous and thus contributing to an increase in the productivity of the waters.

Although the isolated molecule does not present a risk of bioaccumulation, the ligand-metal complexes may significantly increase the bioavailability of extremely dangerous heavy metals. In fact, the dissolution and bioavailability of heavy metals are phenomena worth of greater attention. Vassil et al. Enhanced uptake of heavy metals by plants has been extensively studied due to its potential use in heavy metal phytoextraction technologies, but special attention has been paid to their concomitant lixiviation and migration phenomena It is interesting to note that the same concentration of EDTA chelated with micronutrients did not present these toxic effects.

Greman et al. Research of the cellular toxicity of chelates indicates, in general, noxious effects normally attributed to the lack of metals essential to various cellular functions. The findings of Hugenschmidt et al. However, a recent study proposes carbonyl iron as a better fortificant than NaFeEDTA salts, because it resulted to be less toxic when tested in acute toxicity in young rats Free EDTA has been shown to produce adverse reproductive and developmental effects in mammals.

However, it is considered as a safe substance if used externally; which is relevant considering that EDTA is a common ingredient in cosmetic formulation EDTA has antibacterial activity and metal chelation of the ligand reduces this activity The effect of chelating agents upon gram negative bacteria has been reported.

EDTA causes disruption of the outer membrane, since it is capable of removing its calcic and magnesic divalent cations, with the consequent loss of substantial amounts of lipopolysacharide, which in turn, make cells susceptible to the action of many substances such as detergents, proteases, lipases and lysozymes Hennecken et al.

Paradoxically, even though literature provides evidence of the persistence and low natural degradability of the chelate, the study of its toxicity is basically documented for acute toxicity bioassays and there is not sufficient information for the evaluation of chronic toxicity.

Until recently, it used to be postulated that the concentration of free metals in solution was the main factor in the bioavailability and toxicity of metals. It has also been proved that heavy metals complexed with EDTA and also with humic acids are biologically available and toxic. This has been demonstrated in the study of Tubbing et al. As stated previously, this is also evident in the work of Vassil et al.

These studies show that the formation of the chelate-metal coordination compound, achieves a decrease in the toxicity of free heavy metals. On the contrary Guilhermino et al. Although there is not enough research describing the behavior of the chelate in surface waters, it can be seen that this is a complex, multivariable and dynamic phenomenon, which makes it difficult to predict fate and to quantify the speed of the processes involved.

Some authors warn that the theoretical calculations based on chemical balance are not a useful tool for predicting EDTA speciation in effluents, since the kinetic dimension of the processes of metal interchange cannot be overlooked 32, The influence of the suspended material and the consequent occurrence of adsorption and desorption phenomena on their surface, must be also considered.

The validity of the theoretical approximation is further diminished if account is taken of the fact that EDTA is one of many natural and anthropogenic ligands which can be found in the aquatic medium.

Moreover, the geochemical nature of rocks underlying the type of fresh water studied must be taken into consideration, since this will influence the pH and the provision of metals to the waters.

At present, there is not enough information on the aquatic speciation and on the natural ligands competition phenomena which are crucial for predicting the metal-EDTA complexes environmental fate Table 2 , shows some of the ranges of concentration of EDTA found in natural waters. The highest value has been found in England mgL It could be possible, in theory, to speculate on a continuous photolysis of the complex EDTA-Fe III which would entail the massive degradation of the chelate.

However, Kari and Giger 32 point out the factual impossibility of such phenomenon on the basis of the intensity of light and the adsorption phenomena of photostable complexes of EDTA.

This is in agreement with its relatively high concentrations that have been found in European continental waters 6,7. According to the literature, there may be photolysis under high transparency conditions and in shallow watercourses.

The studies on the photodegradability of EDTA in the environment should also take into account the cloud cover in the sky and suspended material in the waters, since these are factors that condition the intensity of light received by water 32, Jahan et al.

Guo, J. Zhou, X. Chen et al. Reyes, E. Blaurock-Busch, Y. Busch, A. Friedle, H. Buerner, C. Parkash, and A. Akerstrom, L. Barregard, T. Lundh, and G. Rodrigues, J. Serpeloni, B. Batista, S. Souza, and F. Barbosa Jr. View at: Google Scholar E. Magliery, L. Vitellaro, N. Diop, and R. Castro, S. Arandi, S. Haghpanah, S. Safaei et al. Songdej, N.

Sirachainan, P. Wongwerawattanakoon et al. Berdoukas, T. Coates, and Z. Wongjaikam, S. Kumfu, S. Chattipakorn, S. Fucharoen, and N. Calvaruso, A. Vitrano, R. Di Maggio et al. Banerjee, N. Mifsud, R. Bird et al. Ward, D. Dexter, and R. Belaidi and A. Devos, C. Moreau, J. Devedjian et al. Stephenson, N.

Nathoo, Y. Mahjoub, J. Dunn, and V. Kimura, A. Onodera, F. Okumura, T. Nakanishi, and N. Huang, X. Yu, J. Zhang et al. Xu, X. Li, H. Zhu, Y. Liu, F. Fang, and L. View at: Google Scholar M. Rafati-Rahimzadeh, M. Rafati-Rahimzadeh, S. Kazemi, and A. Kobayashi, S. Yokokura, T. Hariya, and T. Exley, U. Ahmed, A. Polwart, and R. Fulgenzi, D. Vietti, and M. Panariti and K. View at: Google Scholar I. Hininger, R. Waters, M. Osman et al. Roussel, I. Hininger-Favier, R. Osman, K. Fernholz, and R.

Madhusudhanan and S. Mikler, P. Banovcin, M. Jesenak, J. Hamzikova, and D. Petracca, F. Scafa, R. Boeri, D. Flachi, and S. Gil, E. Kang, K. Lee, J. Yang, E. Lee, and S. Aoyama and T. Fulgenzi, R. De Giuseppe, F. Bamonti, D. Guldager, K. Brixen, S. Jorgensen, H. Nielsen, L. Mosekilde, and R. Lamas, C. Goertz, R. Boineau et al. Lamas, R. Boineau, C. Goertz et al. Solenkova, J. Newman, J. Berger, G. Thurston, J. Hochman, and G.

Moon, E. Guallar, J. Umans et al. Tellez-Plaza, E. Guallar, B. Howard et al. Ouyang, S. Topic Overview What is chelation therapy? Chelation therapy is performed on an outpatient basis. What is chelation therapy used for?

Is chelation therapy safe? DOI: Accessed October 13, Credits Current as of: September 23, Top of the page Next Section: Related Information.

Previous Section: References Top of the page. Current as of: September 23,