Why does caloric restriction increases lifespan

26 jul. CR has been found to slow aging and increase lifespan in rodents. It also protects against obesity, insulin resistance, hypertension. Caloric restriction (CR), reduction of calorie intake to a level that does not compromise overall health, has been considered as being one of the most promising. However, caloric restriction did not decrease age-associated ocular diseases that involved 50 and 40% of control and calorie-restricted animals over 9 years of.