How does amphetamine work in the brain

Amphetamines can: cause the release of dopamine from axon terminals. All of these actions result in more dopamine in the synaptic cleft where it can act on receptors. Many of the effects of amphetamines are similar to cocaine. Addiction to and withdrawal from amphetamines are both possible. Discovering how amphetamine works in the brain Challenge Amphetamines have long been known to increase dopamine levels and regulate the activity of glutamate—two important neurotransmitters.

Advance Working with cultured mouse neurons, a team led by Susan Amara, Ph. Impact With knowledge of the specific chain of events amphetamines set in motion in the brain, it is now possible to target the cascade of molecules—from outside the cell, to cell membrane, to inside the cell—in the development of better drug therapies in, for example, ADHD. Related Accomplishments Exploring the role of dopamine in cocaine abuse Rewarding social interaction prevents drug addiction in rats Potential compounds for prevention and treatment of prescription opioid abuse Highly selective compound could treat neuropsychiatric disorders with fewer side effects A novel treatment for opioid use disorders Over substances have been identified in chocolate.

Some of these, including caffeine and theobromine another, less powerful stimulant could actually cause dependency effects. But the amounts of these substances in chocolate are too small to really have any effect.

The same goes for phenylethylamine, a substance related to a family of stimulants called amphetamines. For example, chocolate contains less phenylethylamine than goat cheese. Anandamide, a neurotransmitter produced naturally by the brain, has also been isolated in chocolate.

The neural receptors for anandamide are the same ones to which THC, the main active ingredient in cannabis, binds. Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats.

Pflugers Arch. Crow, T. Catecholamine-containing neurones and electrical self-stimulation. A review of some data. Intracranial self stimulation with electrodes in the region of the locus coeruleus. Dahlstrom, A. Localization of monoamines in the lower brain stem. Experientia 20, — Damsma, G. Dopaminergic regulation of striatal cholinergic interneurons: an in vivo microdialysis study. Naunyn Schmiedebergs Arch. Dopaminergic regulation of striatal release: importance of D1 and N -methyl-d-aspartate receptors.

Darke, S. Major physical and psychological harms of methamphetamine use. Drug Alcohol Rev. Darracq, L. Importance of the noradrenaline-dopamine coupling in the locomotor activating effects of D-amphetamine. Date, Y. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.

U S A 96, — Davern, P. A role for the lateral PB nucleus in cardiovascular function and fluid homeostasis. DeBoer, P. Physiological release of striatal acetylcholine in vivo : modulation by D1 and D2 dopamine receptor subtype. Nicotinic and muscarinic cholinergic receptors are recruited by acetylcholine-mediated neurotransmission within the locus coeruleus during the organisation of post-ictal antinociception.

Delle Donne, K. Protection against methamphetamine-induced neurotoxicity to neostriatal dopaminergic neurons by adenosine receptor activation.

Deutch, A. Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area. Devoto, P. Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex. Di Chiara, G. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

U S A 85, — Dickinson, S. Psychopharmacology 96, — Dobbs, L. The role of the laterodorsal tegmental nucleus in methamphetamine conditioned place preference and locomotor activity.

Comparison of systemic and local methamphetamine treatment on acetylcholine and dopamine levels in the ventral tegmental area in the mouse.

Acetylcholine from the mesopontine tegmental nuclei differentially affects methamphetamine induced locomotor activity and neurotransmitter levels in the mesolimbic pathway. Dougalis, A. Functional properties of dopamine neurons and co-expression of vasoactive intestinal polypeptide in the dorsal raphe nucleus and ventro-lateral periaqueductal grey. Dresse, A. Importance of the noradrenergic mesencephalotelencephalic system as an anatomic substrate of autostimulation behavior.

Life Sci. Drew, A. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse 38, 10— Drouin, C. Synapse 43, 51— Dun, S. Cocaine- and amphetamine-regulated transcript peptide-immunoreactivity in adrenergic C1 neurons projecting to the intermediolateral cell column of the rat. Engelman, H. Presynaptic ionotropic receptors and control of transmitter release.

Organization of noradrenergic efferents to arousal-related basal forebrain structures. Norepinephrine at the nexus of arousal, motivation and relapse.

Estabrooke, I. Fos expression in orexin neurons varies with behavioral state. Ferrucci, M. Pathways of methamphetamine toxicity. Fibiger, H. Role of dopamine and norepinephrine in the chemistry of reward. Fleckenstein, A. New insights into the mechanism of action of amphetamines. Fornai, F. Noradrenergic modulation of methamphetamine-induced striatal dopamine depletion. Noradrenaline loss selectivity exacerbates nigrostriatal toxicity in different species of rodents.

Region-and neurotransmitter-dependent species and strain differences in DSPinduced monoamine depletion in rodents. Neurodegeneration 5, — Norepinephrine loss selectively enhances chronic nigrostriatal dopamine depletion in mice and rats. Norepinephrine loss exacerbates methamphetamine-induced striatal dopamine depletion in mice.

Dose-dependent protective effects of apomorphine against methamphetamine-induced nigrostriatal damage. Effects of pretreatment with N- 2-chloroethyl -N-ethylbromobenzylamine DSP-4 on methamphetamine pharmacokinetics and striatal dopamine losses. Similarities between methamphetamine toxicity and proteasome inhibition. Forster, G. Effects of laterodorsal tegmentum excitotoxic lesions on behavioral and dopamine responses evoked by morphine and d-amphetamine.

Fulceri, F. Abnormal involuntary movements AIMs following pulsatile dopaminergic stimulation: severe deterioration and morphological correlates following the loss of locus coeruleus neurons. Gesi, M. Novel aspects of dopamine oxidative metabolism confounding outcomes take place of certainties. Godino, A. Epigenetic landscape of amphetamine and methamphetamine addiction in rodents. Epigenetics 10, — Gompf, H. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.

Grenhoff, J. Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat. Neural Transm. Prazosin modulates the firing pattern of dopamine neurons in rat ventral tegmental area. Gresch, P. Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex.

Guyenet, P. Central noradrenergic neurons: the autonomic connection. The sympathetic control of blood pressure. Rostral ventrolateral medulla and sympathorespiratory integration in rats. Hagan, J. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Hajnal, A. Parabrachial coding of sapid sucrose: relevance to reward and obesity.

Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: evidence for a 5-HT-independent mechanism. Hanson, L. Evidence that the central action of amphetamine is mediated via catecholamines. Psychopharmacologia 9, 78— Harro, J.

Lesioning of locus coeruleus projections by DSP-4 neurotoxin treatment: effect on amphetamine-induced hyperlocomotion and dopamine D2 receptor binding in rats. Hayward, L. Respiratory response to activation or disinhibition of the dorsal periaqueductal gray in rats. Heal, D. Amphetamine, past and present—a pharmacological and clinical perspective. Immunochemical evidence for the existence of adrenaline neurons in the rat brain.

Homer, B. Methamphetamine abuse and impairment of social functioning: a review of the underlying neurophysiological causes and behavioral implications. Hondebrink, L. Neurotoxicology 33, — Hong, W. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.

Howe, P. Simultaneous demonstration of phenylethanolamine N-methyltransferase immunofluorescent and catecholamine fluorescent nerve cell bodies in the rat medulla oblongata.

Neuroscience 5, — Imperato, A. Effects of cocaine and amphetamine on acetylcholine release in the hippocampus and caudate nucleus. Inglis, W. An investigation into the role of the pedunculopontine tegmental nucleus in the mediation of locomotion and orofacial stereotypy induced by d-amphetamine in the rat.

Neuroscience 58, — Iversen, L. The uptake and storage of H3-norepinephrine in the reserpine-pretreated rat heart. Jayanthi, S. Juhila, J. Kalayasiri, R. Addiction , — Keys, A. D1 and D2 dopamine receptor mediation of amphetamine-induced acetylcholine release in nucleus accumbens.

Neuroscience 86, — Kikuchi-Utsumi, K. Kim, M. Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the rat. Kirouac, G. Cardiovascular afferent inputs to ventral tegmental area. Kish, S. Brain choline acetyltransferase activity in chronic, human users of cocaine, methamphetamine, and heroin. Psychiatry 4, 26— Krivanek, J. Protein kinase C in the parabrachial nucleus of rats during conditioned taste aversion induced by amphetamine.

Lategan, A. Suppression of nigrostriatal and mesolimbic dopamine release in vivo following noradrenaline depletion by DSP a microdialysis study.

Lester, D. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci. Li, Y. Collateral projections from the midbrain periaqueductal gray to the nucleus raphe magnus and nucleus accumbens in the rat.

A fluorescent retrograde double-labelling study. Li, C. Neuropsychopharmacology 41, — Li, A. Hindbrain catecholamine neurons activate orexin neurons during systemic glucoprivation in male rats. Endocrinology , — Li, F. Bioenergetics failure and oxidative stress in brain stem mediates cardiovascular collapse associated with fatal methamphetamine intoxication. PLoS One 7:e Limanaqi, F. Epigenetic effects induced by methamphetamine and methamphetamine-dependent oxidative stress.

Lin, M. Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells. Lin, L. Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system. Neuroreport 9, — Liprando, L. Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.

Synapse 52, — Liu, W. Loughlin, S. Locus coeruleus projections to cortex: topography, morphology and collateralization. Lovick, T.

Integrated activity of cardiovascular and pain regulatory systems: role in adaptive behavioural responses. Lu, J. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter.