Edta chelation trial

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This report describes the intent-to-treat comparison of the 4 factorial groups overall and in patients with diabetes. The primary end point was a composite of total mortality, MI, stroke, coronary revascularization, or hospitalization for angina. Specifically, it is believed to remove the calcium and other minerals that promote plaque formation. Heart disease is the leading cause of death in the United States, killing more than 2, Americans each day.

It is estimated that over 61 million Americans have some form of cardiovascular disease, which includes high blood pressure, heart disease, stroke, and congestive heart failure. J Am Stat Assoc. Cox DR. Regression models and life-tables with discussion. J R Stat Soc B. A multiple testing procedure for clinical trials. Discrete sequential boundaries for clinical trials. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.

N Engl J Med. The treatment of coronary artery disease with disodium EDTA: a reappraisal. Am J Cardiol. Lamar CP. Chelation endarterectomy for occlusive atherosclerosis.

J Am Geriatr Soc. Olszewer E, Carter JP. EDTA chelation therapy in chronic degenerative disease. Med Hypotheses. US Food and Drug Administration. Public Health Advisory: edetate disodium marketed as endrate and generic products. Accessed February 22, Ann Intern Med.

Blood lead below 0. A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study. Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy. J Am Coll Cardiol. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. Vitamin C pharmacokinetics: implications for oral and intravenous use. Yoshida H, Kisugi R.

Mechanisms of LDL oxidation. Clin Chim Acta. Golub, MD. Save Preferences. Privacy Policy Terms of Use. This Issue. Views 55, Citations View Metrics. Twitter Facebook More LinkedIn. Original Contribution. Gervasio A. Study Population. End Points. Prespecified Subgroups. Statistical Analysis. Baseline Characteristics. Treatment Adherence. Outcome Events. Subgroup Analyses. Adverse Effects and Safety.

Sensitivity Analyses. Study Limitations. Back to top Article Information. Access your subscriptions. Access through your institution.

Add or change institution. Free access to newly published articles. Purchase access. Rent article Rent this article from DeepDyve. Access to free article PDF downloads. Save your search. Customize your interests. Create a personal account or sign in to:. Further research is needed to fully understand the TACT results. Since this is the first clinical trial to show a benefit of chelation, these results are not, by themselves, sufficient to support the routine use of chelation as a post—heart attack therapy in people with diabetes.

Is more research currently being done on chelation for coronary heart disease? Can chelation therapy have side effects? The most important serious side effects are hypocalcemia abnormally low blood calcium levels and damage to the kidneys.

In the TACT study, which had extensive safety monitoring, 16 percent of people receiving chelation and 15 percent of people receiving the placebo stopped their infusions because of an adverse event. Four of those events were serious; two were in the chelation group one death and two were in the placebo group one death. Do over-the-counter chelation products work?

Are they safe? The FDA has warned the public not to use chelation products that are sold for home use, such as dietary supplements, nasal sprays, or suppositories.