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Chapter PDFs from the Cochrane Handbook for Systematic Reviews of Interventions (v6.3). PDF versions of all chapters are available to registered Cochrane 9781119536611 (adobe pdf) | ISBN 9781119536659 (epub) Work on a handbook to support authors of Cochrane Reviews began in 1993, and the. This Handbook outlines in detail Cochrane's methods for conducting systematic reviews of interventions, including planning, literature searching, This extract is from Handbook version 5.0.1. An assessment of the validity of studies included in a Cochrane review should emphasize the risk.