Drug-Like Properties: Concepts, Structure
Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Li Di, Edward H Kerns
Drug-Like-Properties-Concepts.pdf
ISBN: 9780128010761 | 580 pages | 15 Mb
- Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
- Li Di, Edward H Kerns
- Page: 580
- Format: pdf, ePub, fb2, mobi
- ISBN: 9780128010761
- Publisher: Elsevier Science
Online book download for free Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization PDF by Li Di, Edward H Kerns 9780128010761 (English Edition)
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods
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Integration of drug-like properties in selection, optimization and biological As part of our effort to develop novel concepts in schizophrenia therapy, we Structure Design and Methods: from ADME to Toxicity Optimization,.
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A novel relay method has been developed using cryopreserved human 2011) ( too long a half-life, complex dosing regimen, toxicity due to accumulation, and concerns on metabolic stability during lead optimization and candidate selection. (2008) Drug-like Properties: Concepts, Structure Design and Methods: from
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Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity. Drug-like Properties: Concepts, Structure Design and Methods: from…
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Download pdf #Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization. | #1047381 in eBooks | 2010-07-26
Drug-like Properties : Concepts, Structure Design and Methods from
Drug-like Properties : Concepts, Structure Design and Methods from ADME to Toxicity Optimization (English) 1st Edition. Author: Edward H. Kerns,Li Di.
Drug-like Properties: Concepts, Structure Design and Methods th
and Methods 1st edition. from ADME to Toxicity Optimization. Drug-like Properties: Concepts, Structure Design and Methods 0 9780080557618 0080557619
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